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In a preliminary clinical trial, a potential vaccine for peanut allergies performed well. Peptides, which are peanut proteins, are injected as part of the immunotherapy.
After promising results from a phase I clinical trial, researchers may be one step closer to producing a vaccine for peanut allergies.
PVX108 is an immunotherapy medication that aims to reset the immune system so that people with peanut allergies can be exposed to peanuts without developing an allergic reaction.
The vaccine's safety has been examined in a first clinical trial in Australia over the past 18 months.
Study participants with peanut allergies were given escalating dosages of peanut proteins known as peptides during the study. The vaccine's peptides don't trigger the cells that cause severe reactions to peanuts, lowering the danger for people with the allergy.
The trial's initial stage was intended to examine just the vaccine's safety, with phase II focusing on the treatment's efficacy. However, researchers believe this is a positive step forward.
Dr. Robyn O'Hehir, head of allergy, clinical immunology, and respiratory medicine at Monash University in Melbourne and chief medical advisor to Aravax, the company behind the trial, said, "Although early stage, these results suggest that a peptide-based approach to peanut allergy immunotherapy could offer significant safety advantages over other approaches in later stages of development."
“This is a major step forward in the hunt for a safe medication for peanut allergy, and it builds on previous research revealing that PVX108 targets the peanut-specific T cells that are thought to be the fundamental cause of disease,” she added.
The immune system, which protects the body from viruses and germs, initiates an allergic reaction.
The immune system of people with allergies misinterprets an otherwise harmless substance termed an allergen as a threat. When allergens enter a person's body, the immune system responds by sending antibodies and specific white blood cells to destroy the foreign substance. An allergic reaction occurs as a result of this.
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